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Crushing or chewing the tablets will destroy the extended release properties of the drug. Metoprolol and Carvedilol - Immediate to Extended Release Dose Conversions Metoprolol Immediate (tartrate) -> Extended (succinate) 25 mg BID -> 50 mg daily 50 mg BID -> 100 mg daily 100 mg BID -> 200 mg daily Carvedilol Immediate (IR) -> Extended (ER) 3.125 mg BID -> 10 mg daily 6.25 mg BID -> 20 mg daily 12.5 mg BID -> 40 mg daily 25 mg BID -> 80 mg daily Jarred Prudencio, PharmD - https. It is important to note however that split tablets should be swallowed whole, without chewing or crushing. Each pellet acts as a separate drug delivery unit, which allows the tablet to be cut in half as the pellets will be unaffected with one cut. Metoprolol 25 compared metoprolol succ er 25 3 Answers I have two prescriptions: metoprolol tartarate 25 mg and metoprolol succ er 25 mg. Metoprolol ER tablets contain a large number of tiny controlled release pellets, which are evenly dispersed throughout the tablet. This is not the case for metoprolol ER however.Įxtended-release metoprolol tablets are scored and may be halved. Metoprolol ER Release Mechanismįor most extended release medications, altering the tablet/capsule will destroy the extended release mechanism, causing the entire dose to be delivered at once, which can increase the risk of overdose and side effects. Watch for signs of confusion, dizziness,faster heart beat, tremors (shaking) and increased sweating. Use of Acarbose and Metoprolol Succinate should be avoided at the same time. In fact, it is one of the few extended release medications that is able to be cut safely, which is due to how the extended release mechanism of metoprolol succinate works. Metoloss-ER 25 Tablet & Discarb 25mg Tablet. Yes, Toprol XL (metoprolol succinate extended release) can be cut or split in half. Can Toprol XL (metoprolol succinate extended release) be cut in half? Answer